The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Lifestyle is a well-known environmental factor that plays a major role in facilitating the
development of metabolic syndrome or eventually exacerbating its consequences. Various …

Medical management of obesity represents a large unmet clinical need. Animal experiments
suggest a therapeutic potential for dietary capsaicin, the pungent ingredient in hot chili …

Introduction: With 336 reviews, the capsaicin receptor TRPV1 arguably represent today's
most extensively reviewed analgesic target. TRPV1 is strategically located at the peripheral …

A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …

Today's sedentary lifestyle with too much food and too little exercise has made metabolic
syndrome a pandemic. Metabolic syndrome is a major risk factor for type-2 diabetes and …

Abstract Originating from Eastern Asia, the plant Cannabis sativa has been used for
centuries as a medicinal treatment. The unwanted psychotropic effects of one of its major …

With an estimated 422 million affected patients worldwide in 2016, type 2 diabetes (T2D)
has reached pandemic proportions and represents a major unmet medical need. T2D is a …

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved
among flies to humans. Most TRP channels have well known functions in chemosensation …

Transient receptor potential (TRP) channels are members of an ancient class of ion
channels that are present in most mammalian tissues. Consistent with their wide tissue …