Noise—random disturbances of signals—poses a fundamental problem for information
processing and affects all aspects of nervous-system function. However, the nature, amount …

Changes in the response to release of a single synaptic vesicle have generally been
attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now …

Neuroscience research has exploded, with more than fifty thousand neuroscientists applying
increasingly advanced methods. A mountain of new facts and mechanisms has emerged …

The spatiotemporal organization of neurotransmitter receptors in postsynaptic membranes is
a fundamental determinant of synaptic transmission and information processing by the brain …

Glutamate is the most abundant excitatory neurotransmitter, present at the bulk of cortical
synapses, and participating in many physiologic and pathologic processes ranging from …

Alzheimer′ s disease (AD) is the most common form of dementia in the elderly. Memory
loss in AD is increasingly attributed to soluble oligomers of the amyloid‐β peptide (AβOs) …

The variability of the postsynaptic response following a single action potential arises from
two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to …

The properties of synaptic transmission were first elucidated at the neuromuscular junction.
More recent work has examined transmission at synapses within the brain. Here we review …

Although endocytosis maintains synaptic transmission, how endocytosis is initiated is
unclear. We found that calcium influx initiated all forms of endocytosis at a single nerve …

How synaptic-vesicle release is controlled at the basic release structure, the active zone, is
poorly understood. By performing cell-attached current and capacitance recordings …