[HTML][HTML] Pathogenic role of fibrinogen in the neuropathology of multiple sclerosis: a tale of sorrows and fears

M Alruwaili, HM Al-Kuraishy, A Alexiou… - Neurochemical …, 2023 - Springer
Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the
central nervous system (CNS) due to injury of the myelin sheath by immune cells. The …

Iron in multiple sclerosis–Neuropathology, immunology, and real-world considerations

B Zierfuss, Z Wang, AN Jackson, D Moezzi… - Multiple Sclerosis and …, 2023 - Elsevier
Iron is an essential element involved in a multitude of bodily processes. It is tightly regulated,
as elevated deposition in tissues is associated with diseases such as multiple sclerosis …

[HTML][HTML] Extracellular vesicles in multiple sclerosis: role in the pathogenesis and potential usefulness as biomarkers and therapeutic tools

M D'Anca, C Fenoglio, FR Buccellato, C Visconte… - Cells, 2021 - mdpi.com
Although extracellular vesicles (EVs) were initially relegated to a waste disposal role,
nowadays, they have gained multiple fundamental functions working as messengers in …

Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis

C Natarajan, LHD Le, M Gunasekaran… - Proceedings of the …, 2024 - pnas.org
Multiple sclerosis (MS) is a demyelinating central nervous system (CNS) disorder that is
associated with functional impairment and accruing disability. There are multiple US Food …

[HTML][HTML] Regional contribution of vascular dysfunction in white matter dementia: clinical and neuropathological insights

J Pansieri, G Hadley, A Lockhart, M Pisa… - Frontiers in …, 2023 - frontiersin.org
The maintenance of adequate blood supply and vascular integrity is fundamental to ensure
cerebral function. A wide range of studies report vascular dysfunction in white matter …

[HTML][HTML] Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease

JF Cervilla-Martínez, JJ Rodríguez-Gotor… - International Journal of …, 2022 - mdpi.com
The relationship between Parkinson's disease (PD), the second-most common
neurodegenerative disease after Alzheimer's disease, and palmitoylation, a post …

Analysis of CSF D-dimer to identify intrathecal fibrin-driven autoimmunity in patients with multiple sclerosis

MA Schaller-Paule, Y Yalachkov… - Neurology …, 2022 - AAN Enterprises
Background and Objectives Proteins of the coagulation system contribute to autoimmune
inflammation in patients with multiple sclerosis (MS). On blood-brain barrier (BBB) …

[HTML][HTML] Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

EF Mosleth, CA Vedeler, KH Liland, A McLeod… - Scientific Reports, 2021 - nature.com
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown.
Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis …

Commonly overlooked factors in biocompatibility studies of neural implants

LS Kumosa - Advanced Science, 2023 - Wiley Online Library
Biocompatibility of cutting‐edge neural implants, surgical tools and techniques, and
therapeutic technologies is a challenging concept that can be easily misjudged. For …

Extracellular vesicles as contributors in the pathogenesis of multiple sclerosis

S Zamboni, A D'Ambrosio, P Margutti - Multiple sclerosis and related …, 2023 - Elsevier
Extracellular vesicles (EVs) are a heterogeneous family of extracellular structures bounded
by a phospholipid bilayer, released by all cell types in various biological fluids, such as …