Contemporary synthetic strategies in organofluorine chemistry
R Britton, V Gouverneur, JH Lin, M Meanwell… - Nature Reviews …, 2021 - nature.com
Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …
Visible‐light photocatalysis: does it make a difference in organic synthesis?
Visible‐light photocatalysis has evolved over the last decade into a widely used method in
organic synthesis. Photocatalytic variants have been reported for many important …
organic synthesis. Photocatalytic variants have been reported for many important …
Organic reaction mechanism classification using machine learning
A mechanistic understanding of catalytic organic reactions is crucial for the design of new
catalysts, modes of reactivity and the development of greener and more sustainable …
catalysts, modes of reactivity and the development of greener and more sustainable …
Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …
Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …
interconnected research fields. These include the development of new materials with a …
Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds
G Yan, K Qiu, M Guo - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
The C–F bond is the strongest single bond in organic compounds. It is the most challenging
task to study the activation of the C–F bond in organic synthesis. Trifluoromethyl-containing …
task to study the activation of the C–F bond in organic synthesis. Trifluoromethyl-containing …
A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes
Transition metal–catalyzed arene functionalization has been widely used for molecular
synthesis over the past century. In this arena, copper catalysis has long been considered a …
synthesis over the past century. In this arena, copper catalysis has long been considered a …
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001–2011)
J Wang, M Sánchez-Roselló, JL Aceña… - Chemical …, 2014 - ACS Publications
1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …
Carbon trifluoromethylation reactions of hydrocarbon derivatives and heteroarenes
C Alonso, E Martinez de Marigorta, G Rubiales… - Chemical …, 2015 - ACS Publications
Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …
Transition-metal-free coupling reactions
CL Sun, ZJ Shi - Chemical reviews, 2014 - ACS Publications
Transition-metal-catalyzed reactions have been studied since the very beginning of the past
century and represent a great success in organic chemistry, along with the birth and growth …
century and represent a great success in organic chemistry, along with the birth and growth …
Introduction of fluorine and fluorine‐containing functional groups
T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
were enabled most prominently by organo‐and transition‐metal catalysis. The most …