Early use of high-efficacy disease‑modifying therapies makes the difference in people with multiple sclerosis: an expert opinion

M Filippi, MP Amato, D Centonze, P Gallo… - Journal of …, 2022 - Springer
Multiple sclerosis (MS) is a chronic and progressive neurological disease that is
characterized by neuroinflammation, demyelination and neurodegeneration occurring from …

Diagnosis and classification of optic neuritis

A Petzold, CL Fraser, M Abegg, R Alroughani… - The Lancet …, 2022 - thelancet.com
There is no consensus regarding the classification of optic neuritis, and precise diagnostic
criteria are not available. This reality means that the diagnosis of disorders that have optic …

Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease

EV Mitroshina, MO Savyuk, E Ponimaskin… - Frontiers in cell and …, 2021 - frontiersin.org
Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

BLL Clayton, L Barbar, M Sapar, K Kalpana, C Rao… - Cell Stem Cell, 2024 - cell.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central
nervous system (CNS), resulting in neurological disability that worsens over time. While …

Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges

J Chataway, T Williams, V Li, RA Marrie… - The Lancet …, 2024 - thelancet.com
Despite the success of disease-modifying treatments in relapsing multiple sclerosis, for
many individuals living with multiple sclerosis, progressive disability continues to accrue …

Alterations of oligodendrocyte and myelin energy metabolism in multiple sclerosis

E López-Muguruza, C Matute - International journal of molecular sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …

[HTML][HTML] The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

DSSK Boorgu, S Venkatesh, CM Lakhani… - Multiple sclerosis and …, 2022 - Elsevier
Background To examine whether lower neighborhood-level and individual-level indicators
of socioeconomic status (SES) are associated with subsequently worse neurological …

Piperine improves experimental autoimmune encephalomyelitis (EAE) in lewis rats through its neuroprotective, anti-inflammatory, and antioxidant effects

R Nasrnezhad, S Halalkhor, F Sadeghi… - Molecular …, 2021 - Springer
Inflammation, demyelination, glial activation, and oxidative damage are the most
pathological hallmarks of multiple sclerosis (MS). Piperine, a main bioactive alkaloid of black …

[HTML][HTML] The design, development, and testing of a virtual reality device for upper limb training in people with multiple sclerosis: single-center feasibility study

A Kalron, L Frid, I Fonkatz, S Menascu, M Dolev… - JMIR Serious …, 2022 - games.jmir.org
Background Multiple sclerosis (MS) is a common nontraumatic, neurological, disabling
disease that often presents with upper limb dysfunction. Exercise training has resulted in …

Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption

BA Singer, J Feng, H Chiong-Rivero - Journal of Neurology, 2024 - Springer
Multiple sclerosis (MS) is characterized by progressive neuroinflammation and
neurodegeneration from disease onset that, if left untreated, can result in the accumulation …