Circuits and functions of the lateral habenula in health and in disease
H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …
owing to new discoveries relating to its critical role in regulating negatively motivated …
Dopamine system dysregulation in major depressive disorders
P Belujon, AA Grace - International Journal of …, 2017 - academic.oup.com
Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …
A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system
Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating
motivated behaviors, but the circuitry through which they signal positive and negative …
motivated behaviors, but the circuitry through which they signal positive and negative …
Nucleus accumbens subnuclei regulate motivated behavior via direct inhibition and disinhibition of VTA dopamine subpopulations
Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing.
Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is …
Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is …
VTA GABA neurons at the interface of stress and reward
C Bouarab, B Thompson, AM Polter - Frontiers in neural circuits, 2019 - frontiersin.org
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
Input-specific control of reward and aversion in the ventral tegmental area
Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and
pathological brain functions related to reward and motivation. However, it is unknown …
pathological brain functions related to reward and motivation. However, it is unknown …
Reward and aversion in a heterogeneous midbrain dopamine system
The ventral tegmental area (VTA) is a heterogeneous brain structure that serves a central
role in motivation and reward processing. Abnormalities in the function of VTA dopamine …
role in motivation and reward processing. Abnormalities in the function of VTA dopamine …
Dopamine in motivational control: rewarding, aversive, and alerting
ES Bromberg-Martin, M Matsumoto, O Hikosaka - Neuron, 2010 - cell.com
Midbrain dopamine neurons are well known for their strong responses to rewards and their
critical role in positive motivation. It has become increasingly clear, however, that dopamine …
critical role in positive motivation. It has become increasingly clear, however, that dopamine …
Reward processing by the lateral habenula in normal and depressive behaviors
The brain reward circuit has a central role in reinforcing behaviors that are rewarding and
preventing behaviors that lead to punishment. Recent work has shown that the lateral …
preventing behaviors that lead to punishment. Recent work has shown that the lateral …
GABA neurons of the VTA drive conditioned place aversion
KR Tan, C Yvon, M Turiault, JJ Mirzabekov, J Doehner… - Neuron, 2012 - cell.com
Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral
tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism …
tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism …