Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Oxidative stress basically defines a condition in which prooxidant–antioxidant balance in the
cell is disturbed; cellular biomolecules undergo severe oxidative damage, ultimately …

Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Reactive oxygen species (ROS) are products of normal metabolism and xenobiotic
exposure, and depending on their concentration, ROS can be beneficial or harmful to cells …

Protein quality control systems are crucial for cellular function and organismal health. At
present, most known protein quality control systems are multicomponent machineries that …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

In addition to inducing new transcriptional activities that lead within a few hours to the
accumulation of heat shock proteins (Hsps), heat shock activates within minutes the major …

A single family of proteases, the caspases, has long been considered the pivotal
executioner of all programmed cell death. However, recent findings of evolutionarily …

Apoptosis signal‐regulating kinase (ASK) 1 is activated in response to various cytotoxic
stresses including TNF, Fas and reactive oxygen species (ROS) such as H 2 O 2, and …

Neuronal loss is one of the striking causes of various central nervous system (CNS)
disorders, including major neurodegenerative diseases, such as Alzheimer's disease (AD) …