The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

Intensive research has demonstrated that extracellular matrix (ECM) molecules and growth
factors (GF) collaborate at many different levels. The ability of ECM to modulate GF signals …

Simple Summary Integrins play key roles in mediating cell adhesion and delivering chemical
and mechanical signals to the interior of the cell. Consequently, they actively control cellular …

The insulin-like growth factor (IGF) axis plays important roles in cancer development and
metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long …

Targeted therapy is revolutionizing the treatment of cancers, but resistance evolves against
these therapies and derogates their success. The phosphatidylinositol 3-kinase delta (PI3K …

Lung cancer is a major cancer, leading in both incidence and mortality in the world, and
metastasis underlies the majority of lung cancer–related deaths. Galectin-1, a glycan …

Significance: This critical review focuses on interactions between cells, fibronectin (FN), and
growth factors (GF). Recent Advances: Initially, the extracellular matrix (ECM) was thought to …

Plasma fibrinogen (F1) and fibronectin (pFN) polymerize to form a fibrin clot that is both a
hemostatic and provisional matrix for wound healing. About 90% of plasma F1 has a …