Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

The classification of histamine receptors has to date been based on rigorous classical
pharmacological analysis, and as yet, the classification of the three histamine receptors that …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Some G-protein-coupled receptors display 'constitutive activity', that is, spontaneous activity
in the absence of agonist,,,. This means that a proportion of the receptor population …

The detailed distribution of histamine H3 receptor mRNAs in rat brain was analyzed by in
situ hybridization using a 33P-labelled riboprobe and was combined for the first time with the …

Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and
cell differentiation in many organs, including the developing pancreas,. Here we show that …

Ciproxifan, ie, cyclopropyl-(4-(3-1 H-imidazol-4-yl) propyloxy) phenyl) ketone, belongs to a
novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a …

Within the recent years novel lead optimisations for histamine H3 receptor antagonists made
their way from bench to bedside. Structure–activity relationships, cross-affinities and side …

The recent cloning and characterization of the human histamine H3 receptor cDNA marked
a significant step toward a greater understanding of the role of this receptor in the central …

Histamine, a biological amine, is considered as a principle mediator of many pathological
processes regulating several essential events in allergies and autoimmune diseases. It …