Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …

Acid‐sensing ion channels (ASICs) are a class of trimeric cation‐selective ion channels
activated by changes in pH within the physiological range. They are widely expressed in the …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Ligand-gated ion channels transduce electrochemical signals in neurons and other
excitable cells. Aside from canonical ligands, phospholipids are thought to bind specifically …

Membrane proteins govern critical cellular processes and are central to human health and
associated disease. Understanding of membrane protein function is obscured by the vast …

GLIC, a proton-activated prokaryotic ligand-gated ion channel, served as a model system for
understanding the eukaryotic counterparts due to their structural and functional similarities …

Glycine receptors are ligand-gated ion channels that mediate synaptic inhibition throughout
the mammalian spinal cord, brainstem, and higher brain regions. They have recently …

Ligand-gated ion channels are critical mediators of electrochemical signal transduction
across evolution. Biophysical and pharmacological characterization of these receptor …

Pentameric ligand-gated ion channels (pLGICs) are receptor proteins that are sensitive to
their membrane environment, but the mechanism for how lipids modulate function under …

Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating
electrochemical signaling in neurons and other excitable cells. For many channels, the …