Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …

Compulsive behaviors are driven by repetitive urges and typically involve the experience of
limited voluntary control over these urges, a diminished ability to delay or inhibit these …

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …

Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …

In the present study, we used a mouse model of chronic intermittent ethanol (CIE) exposure
to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute …

Impaired attentional set-shifting and inflexible decision-making are problems frequently
observed during normal aging and in several psychiatric disorders. To understand the …

Deficits in cognitive flexibility, the ability to modify behavior in response to changes in the
environment, contribute to the onset and maintenance of stress-related neuropsychiatric …

Synaptic plasticity mediated by NMDA glutamate receptors is thought to be a primary
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …

Navigation abilities show marked decline in both normal ageing and dementia. Path
integration may be particularly affected, as it is supported by the hippocampus and …

Rationale Cognitive deficits represent a core symptom cluster in schizophrenia (SZ) that is
predictive of outcome but not effectively treated by current antipsychotics. Thus, there is a …