The neural basis of reversal learning: An updated perspective
Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …
and have been used as assays, across species, for altered cognitive processes in a host of …
Compulsivity in obsessive–compulsive disorder and addictions
Compulsive behaviors are driven by repetitive urges and typically involve the experience of
limited voluntary control over these urges, a diminished ability to delay or inhibit these …
limited voluntary control over these urges, a diminished ability to delay or inhibit these …
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex
Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …
absence of sensory stimulation, the foundation of mental representation. Persistent firing …
Eradicating suicide at its roots: preclinical bases and clinical evidence of the efficacy of ketamine in the treatment of suicidal behaviors
D De Berardis, M Fornaro, A Valchera… - International journal of …, 2018 - mdpi.com
Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …
Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex
S Kroener, PJ Mulholland, NN New, JT Gass… - PloS one, 2012 - journals.plos.org
In the present study, we used a mouse model of chronic intermittent ethanol (CIE) exposure
to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute …
to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute …
Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex
GB Bissonette, EM Powell, MR Roesch - Behavioural brain research, 2013 - Elsevier
Impaired attentional set-shifting and inflexible decision-making are problems frequently
observed during normal aging and in several psychiatric disorders. To understand the …
observed during normal aging and in several psychiatric disorders. To understand the …
Deficits in cognitive flexibility induced by chronic unpredictable stress are associated with impaired glutamate neurotransmission in the rat medial prefrontal cortex
JD Jett, SE Bulin, LC Hatherall, CM McCartney… - Neuroscience, 2017 - Elsevier
Deficits in cognitive flexibility, the ability to modify behavior in response to changes in the
environment, contribute to the onset and maintenance of stress-related neuropsychiatric …
environment, contribute to the onset and maintenance of stress-related neuropsychiatric …
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear
Synaptic plasticity mediated by NMDA glutamate receptors is thought to be a primary
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …
Ageing effects on path integration and landmark navigation
Navigation abilities show marked decline in both normal ageing and dementia. Path
integration may be particularly affected, as it is supported by the hippocampus and …
integration may be particularly affected, as it is supported by the hippocampus and …
Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine
KS Alexander, HQ Wu, R Schwarcz, JP Bruno - Psychopharmacology, 2012 - Springer
Rationale Cognitive deficits represent a core symptom cluster in schizophrenia (SZ) that is
predictive of outcome but not effectively treated by current antipsychotics. Thus, there is a …
predictive of outcome but not effectively treated by current antipsychotics. Thus, there is a …