Introns are ubiquitous in eukaryotic genomes and have long been considered as 'junk
RNA'but the huge energy expenditure in their transcription, removal, and degradation …

A major hurdle for single particle cryo-EM in structural determination lies in the specimen
preparation impaired by the air-water interface (AWI) and preferential particle-orientation …

The group II intron ribonucleoprotein is an archetypal splicing system with numerous
mechanistic parallels to the spliceosome, including excision of lariat introns,. Despite the …

Group II introns are ribozymes that catalyze their self-excision and function as retroelements
that invade DNA. As retrotransposons, group II introns form ribonucleoprotein (RNP) …

RNAs are critical for complex cellular functions, characterized by their structural versatility
and ability to undergo conformational transitions in response to cellular cues. The elusive …

The group II introns are self-splicing ribozymes intervened between two exons that undergo
excision and exon ligation through lariat formation, which are considered as ancestral forms …

Group II introns can self-splice from RNA transcripts through branching, hydrolysis and
circularization, being released as lariats, linear introns and circles, respectively. In contrast …

Pre-mRNA processing is a critical metabolic step in eukaryotes. RNA transcripts must be
spliced, polyadenylated, and capped, among other modifications, to ensure their proper …

Group II intron ribozymes undergo dramatic structural rearrangements to self-splice and
retrohome. The group II intron branching pathway is of evolutionary importance as it is …

Thermophilic group II intron is one type of retrotransposon composed of intron RNA and
intron-encoded protein (IEP), which can be utilized in gene targeting by harnessing their …