Mitosis mediates the accurate separation of daughter cells, and abnormalities are closely
related to cancer progression. KIF11, a member of the kinesin family, plays a vital role in the …

The neurofibromatosis syndromes, including NF1, NF2, and schwannomatosis, are tumor
suppressor syndromes characterized by multiple nervous system tumors, particularly …

Hepatocellular carcinoma (HCC) is a common malignant cancer with poor survival
outcomes, and hepatitis B virus (HBV) infection is most likely to contribute to HCC. But the …

Background Lung adenocarcinoma (LUAD) is challenging in clinical practice due to the poor
understanding of molecular mechanisms and limited therapeutic targets. Herein, the work …

Inhibitors of the mitotic kinesin Kif11 are anti-mitotics that, unlike vinca alkaloids or taxanes,
do not disrupt microtubules and are not neurotoxic. However, development of resistance has …

The mitotic spindle, a self-constructed microtubule-based machine, segregates
chromosomes during cell division. In mammalian cells, microtubule bundles called …

Self-antigens abnormally expressed on tumors, such as MUC1, have been targeted by
therapeutic cancer vaccines. We recently assessed in two clinical trials in a preventative …

驱动蛋白家族成员15 (kinesin family member 15, KIF15) 是驱动蛋白超家族的一员,
在有丝分裂和神经元发育中发挥重要作用, 近年来关于KIF15 在肿瘤中的研究逐渐增多. KIF15 …

BACKGROUND Epithelioid malignant peripheral nerve sheath tumor (EMPNST) of the
bladder is a rare entity with devastating features. These tumors are thought to originate from …

Background: Kinesin family member 15 (KIF15) is a protein that regulates cell mitosis and
plays an important role in the development and progression of several types of human …