Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

A natural products solution to diabetic nephropathy therapy

Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

[HTML][HTML] Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3

HJ Sun, SP Xiong, X Cao, L Cao, MY Zhu, ZY Wu… - Redox biology, 2021 - Elsevier
Diabetic kidney disease is known as a major cause of chronic kidney disease and end stage
renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are …

Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation

L Xie, Y Gu, M Wen, S Zhao, W Wang, Y Ma, G Meng… - Diabetes, 2016 - Am Diabetes Assoc
Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-
inflammatory properties that can regulate multiple cardiovascular functions. However, its …

[HTML][HTML] The roles of gut microbiota and its metabolites in diabetic nephropathy

H Zhao, CE Yang, T Liu, MX Zhang, Y Niu… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which
increases the risk of renal failure and causes a high global disease burden. Due to the lack …

Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets

J Barrera‐Chimal, F Jaisser - Diabetes, Obesity and …, 2020 - Wiley Online Library
Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

[HTML][HTML] lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy

X Zhou, W Zhang, M Jin, J Chen, W Xu, X Kong - Cell death & disease, 2017 - nature.com
We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the
expression of long non-coding RNA myocardial infarction–associated transcript (MIAT) was …

[HTML][HTML] lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy

X Li, H Wang, B Yao, W Xu, J Chen, X Zhou - Scientific reports, 2016 - nature.com
We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the
expression of lncRNA H19 was significantly downregulated. The present study was …

[HTML][HTML] Role of hydrogen sulfide in NRF2-and sirtuin-dependent maintenance of cellular redox balance

T Corsello, N Komaravelli, A Casola - Antioxidants, 2018 - mdpi.com
Hydrogen sulfide (H2S) has arisen as a critical gasotransmitter signaling molecule
modulating cellular biological events related to health and diseases in heart, brain, liver …

[HTML][HTML] Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

V Citi, A Martelli, E Gorica, S Brogi, L Testai… - Journal of advanced …, 2021 - Elsevier
Background The vascular endothelium represents a fundamental mechanical and biological
barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes …