Previous studies have revealed the anti-inflammatory and neuroprotective properties of
Hericium erinaceus extracts, including the fact that the active ingredient erinacine C (EC) …

Pin1 is an enzyme that specifically recognizes the peptide bond between phosphorylated
serine or threonine (pS/pT‐P) and proline. This recognition causes a conformational change …

Pin1 (Protein interacting with NIMA1) is a peptidyl prolyl cis–trans isomerase (PPIase) which
specifically catalyze the conformational conversion of the amide bond of pSer/Thr-Pro motifs …

By controlling the change of the backbones of several cellular substrates, the peptidyl-prolyl
cis-trans isomerase Pin1 acts as key fine-tuner and amplifier of multiple signaling pathways …

Aging of tendon stem/progenitor cells (TSPCs) can lead to tissue degeneration and
subsequent injury. However, the molecular mechanisms controlling TSPC aging are not …

T cells engineered to express artificial chimeric antigen receptors (CARs) that selectively
target tumor-specific antigens or deleterious cell types offer transformative therapeutic …

Cell fusion is a fundamental biological event that is essential for the development of
multinucleated cells such as osteoclasts. Fusion failure leads to the accumulation of dense …

Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond
rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel …

In this study, mathematical and statistical approaches to QSAR-2D modeling were used to
predict biological activity against PIN1 and to explain the origin of the activity of these …

Pin1, the only known isomerase catalyzing phosphorylated pSer/pThr-Pro motifs in proteins,
plays unique roles in human diseases notably cancers and Alzheimer's disease. Herein, site …