In patients with heart failure, plasma levels of atrial natriuretic peptide (ANP), B-type
natriuretic peptide (BNP), and the N-terminal fragments of their prohormones (N-ANP and N …

Cardiac hypertrophy is a complex and nonhomogenous response to various stimuli. In this
study, we used high-density oligonucleotide microarray to examine gene expression profiles …

The zinc finger transcription factor GATA-4 has been implicated as a critical regulator of
inducible cardiac gene expression and as a potential mediator of the hypertrophic program …

PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-
function PIEZO1 mutations are associated with dehydrated hereditary stomatocytosis (DHS) …

The natriuretic peptide system (NPS) is the key driving force of the heart's endocrine
function. Recent developments in NPS-targeted therapies have been found promising and …

Transcription factors are fundamental regulators of gene transcription, and many diseases,
such as heart diseases, are associated with deregulation of transcriptional networks. In the …

Objectives: We investigated the relationship between the urinary levels of biopyrrins and the
severity of heart failure (HF). Background: Oxidative stress is evident in heart disease and …

Aims Heart growth and function are angiogenesis-dependent, but little is known concerning
the effects of key regulators of angiogenesis on diastolic heart failure. Here, we tested the …

Background—B-type natriuretic peptide (BNP) is an endogenous peptide produced under
physiological and pathological conditions mainly by ventricular myocytes. It has natriuretic …

Exposure of experimental animals to increased angiotensin II (ANG II) induces hypertension
associated with cardiac hypertrophy, inflammation, and myocardial necrosis and fibrosis …