Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Aptasensors for pesticide detection

M Liu, A Khan, Z Wang, Y Liu, G Yang, Y Deng… - Biosensors and …, 2019 - Elsevier
Pesticide contamination has become one of the most serious problems of public health in
the world, due to their wide application in agriculture industry to guarantee the crop yield …

Current signal amplification strategies in aptamer-based electrochemical biosensor: A review

L He, R Huang, P Xiao, Y Liu, L Jin, H Liu, S Li… - Chinese Chemical …, 2021 - Elsevier
Due to their high specificity and affinity towards various targets, along with other unique
advantages such as stability and low cost, aptamers are widely applied in analytical …

A review on methods for diagnosis of breast cancer cells and tissues

Z He, Z Chen, M Tan, S Elingarami, Y Liu, T Li… - Cell …, 2020 - Wiley Online Library
Breast cancer has seriously been threatening physical and mental health of women in the
world, and its morbidity and mortality also show clearly upward trend in China over time …

Aptamers entirely built from therapeutic nucleoside analogues for targeted cancer therapy

L Zhu, J Yang, Y Ma, X Zhu… - Journal of the American …, 2022 - ACS Publications
Owing to the specific and high binding affinity of aptamers to their targets, aptamer–drug
conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer …

Aptamers from random sequence space: Accomplishments, gaps and future considerations

S Qian, D Chang, S He, Y Li - Analytica Chimica Acta, 2022 - Elsevier
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …

[HTML][HTML] An ultrasensitive hybridization chain reaction-amplified CRISPR-Cas12a aptasensor for extracellular vesicle surface protein quantification

S Xing, Z Lu, Q Huang, H Li, Y Wang, Y Lai, Y He… - Theranostics, 2020 - ncbi.nlm.nih.gov
Tumor-derived extracellular vesicle (TEV) protein biomarkers facilitate cancer diagnosis and
prognostic evaluations. However, the lack of reliable and convenient quantitative methods …

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

R Liu, L He, Y Hu, Z Luo, J Zhang - Chemical Science, 2020 - pubs.rsc.org
Rapid and accurate diagnosis of COVID-19 plays an essential role in the current epidemic
prevention and control. Despite the promise of nucleic acid and antibody tests, there is still a …

Monitoring and detection of antibiotic residues in animal derived foods: Solutions using aptamers

Y Liu, Y Deng, S Li, FWN Chow, M Liu, N He - Trends in Food Science & …, 2022 - Elsevier
Background Food safety has long been one of the greatest problems in public health.
Among all the food safety problems, antibiotic residues in animal derived foods are one of …

Translation of aptamers toward clinical diagnosis and commercialization

S Liu, Y Xu, X Jiang, H Tan, B Ying - Biosensors and Bioelectronics, 2022 - Elsevier
The dominance of antibodies in diagnostics has gradually changed following the discovery
of aptamers in the early 1990s. Aptamers offer inherent advantages over traditional …