[HTML][HTML] The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials

H Duan, LJ Wang, M Huangfu, H Li - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Short-chain fatty acids (SCFAs) derived from the fermentation of carbohydrates by gut
microbiota play a crucial role in regulating host physiology. Among them, acetate …

Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships

A Paul, S Nahar, P Nahata, A Sarkar, A Maji… - European Journal of …, 2024 - Elsevier
Free fatty acid receptor 1 (FFAR1 or GPR40) is a potential target for treating type 2 diabetes
mellitus (T2DM) and related disorders that have been extensively researched for many …

[HTML][HTML] Based on electronic nose and multi-omics, investigate the dynamic changes of volatile and non-volatile organic compounds in waxy wheat Baijiu from …

P Zhang, J Liu, H Li, Y Ma, Z Pu, L Li, L Huang… - Food Chemistry: X, 2024 - Elsevier
Chinese baijiu is highly regarded for its unique flavor, and a variety of crops can be utilized
as raw materials in its production. Waxy crops are essential ingredients in the brewing of …

Emerging roles of lipid and metabolic sensing in the neuroendocrine control of body weight and reproduction

E Rodríguez-Vázquez, Á Aranda-Torrecillas… - Frontiers in …, 2024 - frontiersin.org
The hypothalamus lies at the intersection of brain and hormonal mechanisms governing
essential bodily functions, including metabolic/body weight homeostasis and reproduction …

Differential Modulation of Catecholamine and Adipokine Secretion by the Short Chain Fatty Acid Receptor FFAR3 and α2-Adrenergic Receptors in PC12 Cells

D Nagliya, T Baggio Lopez, G Del Calvo… - International Journal of …, 2024 - mdpi.com
Sympathetic nervous system (SNS) hyperactivity is mediated by elevated catecholamine
(CA) secretion from the adrenal medulla, as well as enhanced norepinephrine (NE) release …

[HTML][HTML] Novel Phenoxyalkanoic Acid Derivatives as Free Fatty Acid Receptor 4 Agonists for Treating Type 2 Diabetes Mellitus

X Li, X Zhang, X Xie, T Dong, C Lv, R Guan… - International Journal of …, 2024 - mdpi.com
Diabetes mellitus (DM) is a common metabolic disease that poses a severe threat to human
health. Despite a range of therapeutic approaches, there remains a lack of effective and safe …

The effect of educational intervention based on social support theory on the perceived stress caused by the covid-19 pandemic in patients with diabetes in hormozgan …

R Taheri Kondar, L Hassani, A Ghanbarnejad - BMC Public Health, 2024 - Springer
Background People with diabetes are more at risk of covid-19. Perceived social support
plays an important role in maintaining people's health and reducing the negative effects of …

Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs …

A Binienda, K Owczarek, M Sałaga, J Fichna - Pharmacological Reports, 2024 - Springer
Introduction Free fatty acid receptors (FFARs) are G protein-coupled receptors that divide
into 4 subtypes; FFAR2 and FFAR3 are activated by short-chain fatty acids, while FFAR1 …

Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy

E Burgermeister - International Journal of Molecular Sciences, 2023 - mdpi.com
The three major MAP-kinase (MAPK) pathways, ERK1/2, p38 and JNK/SAPK, are upstream
regulators of the nuclear “hormone” receptor superfamily (NHRSF), with a prime example …

[HTML][HTML] The Effectiveness of Online Cognitive-Behavioral Stress Management Training on Blood Glucose Control and Problems in Sexual Function of Married Women …

S Mottaghi, I Rahimian Boogar, S Moradi… - Journal of Rafsanjan …, 2023 - journal.rums.ac.ir
Materials and Methods: This experimental study was conducted with a pretest-posttest
design with a control group. The statistical population included all diabetic married women …