The scientific premise, design, and structure-function analysis of chemical-based muscle
membrane stabilizing block copolymers are reviewed here for applications in striated …

The phospholipid bilayer membrane that surrounds each cell in the body represents the first
and last line of defense for preserving overall cell viability. In several forms of cardiac and …

Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in
conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared …

Abstract Rationale: The FDA-approved Dimethyl Fumarate (DMF) as an oral drug for
Multiple Sclerosis (MS) treatment based on its immunomodulatory activities. However, it also …

Glycerol is the most widely used cryoprotectant for rooster sperm because it declines the
mechanical damage to sperm during the freezing process. Despite its high molecular weight …

Background: Poloxamer 188 (P188) possesses anti-inflammatory properties and can help to
maintain plasma membrane function. P188 has been reported to exert beneficial effects in …

Poloxamer 188 (P188) is an FDA-approved biocompatible block copolymer composed of
repeating units of Poly (Ethylene Oxide)(PEO) and poly (propylene oxide)(PPO). Due to its …

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. There are no
effective therapies available for TBI patients. Vepoloxamer is an amphiphilic polyethylene …

Background: Alzheimer's disease (AD) is initiated by aberrant accumulation of amyloid beta
(Aβ) protein in the brain parenchyma. The microenvironment surrounding amyloid plaques …

Amyotrophic lateral sclerosis (ALS) is a progressive incurable neurodegenerative disease,
which is characterized by selective death of the motoneurons of the spinal cord and brain …