Function and evolution of upstream ORFs in eukaryotes
There is growing interest in the role of translational regulation in cellular homeostasis during
organismal development. Translation initiation is the rate-limiting step in mRNA translation …
organismal development. Translation initiation is the rate-limiting step in mRNA translation …
Heterogeneity in mRNA translation
S Sonneveld, BMP Verhagen, ME Tanenbaum - Trends in cell biology, 2020 - cell.com
During mRNA translation, the genetic information stored in mRNA is translated into a protein
sequence. It is imperative that the genetic information is translated with high precision …
sequence. It is imperative that the genetic information is translated with high precision …
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Abstract Genome‐, transcriptome‐and proteome‐wide measurements provide insights into
how biological systems are regulated. However, fundamental aspects relating to which …
how biological systems are regulated. However, fundamental aspects relating to which …
Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis
MA Ferrada, S Savic, DO Cardona… - Blood, The Journal …, 2022 - ashpublications.org
Somatic mutations in UBA1 cause vacuoles, E1 ubiquitin-activating enzyme, X-linked,
autoinflammatory somatic (VEXAS) syndrome, an adult-onset inflammatory disease with an …
autoinflammatory somatic (VEXAS) syndrome, an adult-onset inflammatory disease with an …
Recommendations for interpreting the loss of function PVS1 ACMG/AMP variant criterion
The 2015 ACMG/AMP sequence variant interpretation guideline provided a framework for
classifying variants based on several benign and pathogenic evidence criteria, including a …
classifying variants based on several benign and pathogenic evidence criteria, including a …
CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise
We assembled the sequences from deep RNA sequencing experiments by the Genotype-
Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts …
Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts …
Most non-canonical proteins uniquely populate the proteome or immunopeptidome
Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the
contribution of non-canonical translation to the proteome and major histocompatibility …
contribution of non-canonical translation to the proteome and major histocompatibility …
[HTML][HTML] Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decoding
Summary mRNA translation is a key step in decoding genetic information. Genetic decoding
is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized …
is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized …
Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
IP Ivanov, JA Saba, CM Fan, J Wang… - Proceedings of the …, 2022 - National Acad Sciences
Translation start site selection in eukaryotes is influenced by context nucleotides flanking the
AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a …
AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a …
[HTML][HTML] Large-scale discovery of non-conventional peptides in maize and Arabidopsis through an integrated peptidogenomic pipeline
Abstract Non-conventional peptides (NCPs), which include small open reading frame-
encoded peptides, play critical roles in fundamental biological processes. In this study, we …
encoded peptides, play critical roles in fundamental biological processes. In this study, we …