Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
Sporozoite immunization: innovative translational science to support the fight against malaria
TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a …
Background WHO recently approved a partially effective vaccine that reduces clinical
malaria in children, but increased vaccine activity is required to pursue malaria elimination …
malaria in children, but increased vaccine activity is required to pursue malaria elimination …
[HTML][HTML] Safety, immunogenicity, and protective efficacy against controlled human malaria infection of Plasmodium falciparum sporozoite vaccine in Tanzanian adults
SA Jongo, SA Shekalaghe, LWP Church… - The American journal …, 2018 - ncbi.nlm.nih.gov
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI)
of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ)(PfSPZ …
of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ)(PfSPZ …
[HTML][HTML] Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections
A Barry, J Bradley, W Stone, MW Guelbeogo… - Nature …, 2021 - nature.com
Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and
incident infections. In the current study, we assess parasite kinetics and infectivity to …
incident infections. In the current study, we assess parasite kinetics and infectivity to …
[HTML][HTML] A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection
B Mordmüller, Z Sulyok, M Sulyok, Z Molnar… - npj Vaccines, 2022 - nature.com
Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in
PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria …
PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria …
[HTML][HTML] Immunogenicity and protective efficacy of radiation-attenuated and chemo-attenuated PfSPZ vaccines in Equatoguinean adults
SA Jongo, V Urbano, LWP Church, A Olotu… - The American journal …, 2021 - ncbi.nlm.nih.gov
Plasmodium falciparum sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified,
cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ …
cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ …
[HTML][HTML] Safety and differential antibody and T-cell responses to the Plasmodium falciparum sporozoite malaria vaccine, PfSPZ vaccine, by age in Tanzanian adults …
SA Jongo, LWP Church, AT Mtoro… - The American journal …, 2019 - ncbi.nlm.nih.gov
In 2016, there were more cases and deaths caused by malaria globally than in 2015. An
effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria® …
effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria® …
Controlled human malaria infection of healthy adults with lifelong malaria exposure to assess safety, immunogenicity, and efficacy of the asexual blood stage malaria …
JC Dejon-Agobe, U Ateba-Ngoa… - Clinical Infectious …, 2019 - academic.oup.com
Background GMZ2 is a recombinant malaria vaccine inducing immune responses against
Plasmodium falciparum (Pf) merozoite surface protein-3 and glutamate-rich protein. We …
Plasmodium falciparum (Pf) merozoite surface protein-3 and glutamate-rich protein. We …
[HTML][HTML] Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity
Controlled human infections provide opportunities to study the interaction between the
immune system and malaria parasites, which is essential for vaccine development. Here, we …
immune system and malaria parasites, which is essential for vaccine development. Here, we …