Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Ubiquitination regulates many essential cellular processes in eukaryotes. This post-
translational modification (PTM) is typically achieved by E1, E2, and E3 enzymes that …

The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

The DNA-dependent protein kinase (DNA-PK) plays an instrumental role in the overall
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …

Activation of the p53 protein protects the organism against the propagation of cells that carry
damaged DNA with potentially oncogenic mutations. MDM2, a p53-specific E3 ubiquitin …

The Mdm2 oncoprotein promotes cell survival and cell cycle progression by inhibiting the
p53 tumor suppressor protein. To regulate p53, Mdm2 must gain nuclear entry, and the …

Activation of p53-mediated transcription is a critical cellular response to DNA damage. p53
stability and site-specific DNA-binding activity and, therefore, transcriptional activity, are …

In multicellular organisms, mutations in somatic cells affecting critical genes that regulate
cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious …

Functional inactivation of p53 by gene mutation and deletion, protein degradation, or viral
oncogene binding renders a mammalian cell susceptible to oncogenic stimuli and …

Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine
residues including S20, a site that is particularly important in regulating stability and function …