Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

CD8+ T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a
complex multifactorial chronic disease. Here, we present an overview of the current research …

Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …

Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …

The aryl-hydrocarbon receptor (AHR) is a ligand-activated transcription factor that buoys
intestinal immune responses. AHR induces its own negative regulator, the AHR repressor …

Pathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …

Celiac disease (CD) is an autoimmune disease in which intestinal inflammation is induced
by dietary gluten. The means through which gluten-specific CD4+ T cell activation …

Abstract γδ T cells perform heterogeneous functions in homeostasis and disease across
tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a …

T cells differentiate into highly diverse subsets and display plasticity depending on the
environment. Although lymphocytes are key mediators of inflammation, functional …

In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …