New targets for schizophrenia treatment beyond the dopamine hypothesis
Schizophrenia has been primarily associated with dopamine dysfunction, and treatments
have been developed that target the dopamine pathway in the central nervous system …
have been developed that target the dopamine pathway in the central nervous system …
Linking inflammation, aberrant glutamate-dopamine interaction, and post-synaptic changes: translational relevance for schizophrenia and antipsychotic treatment: a …
A de Bartolomeis, A Barone, L Vellucci, B Mazza… - Molecular …, 2022 - Springer
Evidence from clinical, preclinical, and post-mortem studies supports the
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …
Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain
A De Rosa, A Fontana, T Nuzzo, M Garofalo, A Di Maio… - Schizophrenia, 2022 - nature.com
Schizophrenia is a disorder of synaptic plasticity and aberrant connectivity in which a major
dysfunction in glutamate synapse has been suggested. However, a multi-level approach …
dysfunction in glutamate synapse has been suggested. However, a multi-level approach …
The role of G protein-coupled receptors (GPCRs) and calcium signaling in schizophrenia. Focus on GPCRs activated by neurotransmitters and chemokines
T Boczek, J Mackiewicz, M Sobolczyk, J Wawrzyniak… - Cells, 2021 - mdpi.com
Schizophrenia is a common debilitating disease characterized by continuous or relapsing
episodes of psychosis. Although the molecular mechanisms underlying this psychiatric …
episodes of psychosis. Although the molecular mechanisms underlying this psychiatric …
Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice
Background Enhanced supraspinal glutamate levels following nerve injury are associated
with pathophysiological mechanisms responsible for neuropathic pain. Chronic pain can …
with pathophysiological mechanisms responsible for neuropathic pain. Chronic pain can …
Drug design targeting the muscarinic receptors and the implications in central nervous system disorders
There is substantial evidence that cholinergic system function impairment plays a significant
role in many central nervous system (CNS) disorders. During the past three decades …
role in many central nervous system (CNS) disorders. During the past three decades …
Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of …
Ethnopharmacological relevance Persistent ketamine insults to the central nervous system
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …
Rational and translational implications of D-amino acids for treatment-resistant schizophrenia: from neurobiology to the clinics
A de Bartolomeis, L Vellucci, MC Austin, G De Simone… - Biomolecules, 2022 - mdpi.com
Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …
Dysregulations of synaptic vesicle trafficking in schizophrenia
CN Egbujo, D Sinclair, CG Hahn - Current psychiatry reports, 2016 - Springer
Schizophrenia is a serious psychiatric illness which is experienced by about 1% of
individuals worldwide and has a debilitating impact on perception, cognition, and social …
individuals worldwide and has a debilitating impact on perception, cognition, and social …
Treating the synapse in major psychiatric disorders: the role of postsynaptic density network in dopamine-glutamate interplay and psychopharmacologic drugs …
Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …