Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
A brief review on the Human Encyclopedia of DNA Elements (ENCODE) project
H Qu, X Fang - Genomics, proteomics & bioinformatics, 2013 - academic.oup.com
Abstract The ENCyclopedia Of DNA Elements (ENCODE) project is an international
research consortium that aims to identify all functional elements in the human genome …
research consortium that aims to identify all functional elements in the human genome …
[HTML][HTML] An integrated encyclopedia of DNA elements in the human genome
ENCODE Project Consortium - Nature, 2012 - ncbi.nlm.nih.gov
The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers
Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the
COMPASS (com plex of p roteins as sociated with S et1) family from Saccharomyces …
COMPASS (com plex of p roteins as sociated with S et1) family from Saccharomyces …
Transcriptional dysregulation of MYC reveals common enhancer-docking mechanism
Transcriptional dysregulation of the MYC oncogene is among the most frequent events in
aggressive tumor cells, and this is generally accomplished by acquisition of a super …
aggressive tumor cells, and this is generally accomplished by acquisition of a super …
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C
NH Dryden, LR Broome, F Dudbridge… - Genome …, 2014 - genome.cshlp.org
Genome-wide association studies have identified more than 70 common variants that are
associated with breast cancer risk. Most of these variants map to non-protein-coding regions …
associated with breast cancer risk. Most of these variants map to non-protein-coding regions …
Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor
Background & Aims Increasing grade of pancreatic intraepithelial neoplasia (PanIN) has
been associated with progression to pancreatic ductal adenocarcinoma (PDAC). However …
been associated with progression to pancreatic ductal adenocarcinoma (PDAC). However …
Inferring regulatory element landscapes and transcription factor networks from cancer methylomes
Recent studies indicate that DNA methylation can be used to identify transcriptional
enhancers, but no systematic approach has been developed for genome-wide identification …
enhancers, but no systematic approach has been developed for genome-wide identification …
Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling
Organs are anatomically compartmentalised to cater for specialised functions. In the small
intestine (SI), regionalisation enables sequential processing of food and nutrient absorption …
intestine (SI), regionalisation enables sequential processing of food and nutrient absorption …
A novel wnt regulatory axis in endometrioid endometrial cancer
Abstract The Protocadherin 10 (PCDH10) is inactivated often by promoter hypermethylation
in various human tumors, but its possible functional role as a tumor suppressor gene is not …
in various human tumors, but its possible functional role as a tumor suppressor gene is not …