A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Peptide-binding proteins play key roles in biology, and predicting their binding specificity is
a long-standing challenge. While considerable protein structural information is available, the …

Abstract Human Leukocyte Antigen (HLA) is a type of molecule residing on the surfaces of
most human cells and exerts an essential role in the immune system responding to the …

Motivation Increasingly comprehensive characterization of cancer-associated genetic
alterations has paved the way for the development of highly specific therapeutic vaccines …

Fundamental clinical areas such as drug delivery and regenerative medicine require
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …

Human leukocyte antigen class I (HLA-I) molecules bind intracellular peptides produced by
protein hydrolysis and present them to the T cells for immune recognition and response …

The study of bioactive molecules of marine origin has created an important bridge between
biological knowledge and its applications in biotechnology and biomedicine. Current studies …

Motivation Computationally predicting major histocompatibility complex (MHC)-peptide
binding affinity is an important problem in immunological bioinformatics. Recent cutting …

Abstract Major Histocompatibility Complex (MHC) plays a major role in the adaptive immune
response by recognizing foreign proteins through binding to their peptides. In humans alone …