Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

JD Radolf, RK Deka, A Anand, D Šmajs… - Nature Reviews …, 2016 - nature.com
The past two decades have seen a worldwide resurgence in infections caused by
Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity …

Biological basis for syphilis

RE LaFond, SA Lukehart - Clinical microbiology reviews, 2006 - Am Soc Microbiol
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp.
pallidum. Clinical manifestations separate the disease into stages; late stages of disease are …

Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins

B Henderson, S Nair, J Pallas… - FEMS microbiology …, 2011 - academic.oup.com
Fibronectin, a large and essential multidomain glycoprotein, with multiple adhesive
properties, functioning as a key link between cells and their extracellular matrices, is now …

Syphilis: using modern approaches to understand an old disease

EL Ho, SA Lukehart - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and
both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the …

Physiological Osmotic Induction of Leptospira interrogans Adhesion: LigA and LigB Bind Extracellular Matrix Proteins and Fibrinogen

HA Choy, MM Kelley, TL Chen, AK Møller… - Infection and …, 2007 - Am Soc Microbiol
Transmission of leptospirosis occurs through contact of mucous membranes and abraded
skin with freshwater contaminated by pathogenic Leptospira spp. Exposure to physiological …

A newly identified leptospiral adhesin mediates attachment to laminin

AS Barbosa, PAE Abreu, FO Neves… - Infection and …, 2006 - Am Soc Microbiol
Pathogenic leptospires have the ability to survive and disseminate to multiple organs after
penetrating the host. Several pathogens, including spirochetes, have been shown to …

Characterization of Novel Bovine Gastrointestinal Tract Treponema Isolates and Comparison with Bovine Digital Dermatitis Treponemes

NJ Evans, JM Brown, RD Murray, B Getty… - Applied and …, 2011 - Am Soc Microbiol
This study aimed to isolate and characterize treponemes present in the bovine
gastrointestinal (GI) tract and compare them with bovine digital dermatitis (BDD) …

Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection

S Houston, A Gomez, A Geppert, A Eshghi, DS Smith… - Scientific Reports, 2023 - nature.com
Comprehensive proteome-wide analysis of the syphilis spirochete, Treponema pallidum
ssp. pallidum, is technically challenging due to high sample complexity, difficulties with …

A Novel Treponema pallidum Antigen, TP0136, Is an Outer Membrane Protein That Binds Human Fibronectin

MB Brinkman, MA McGill, J Pettersson… - Infection and …, 2008 - Am Soc Microbiol
The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of
Treponema pallidum subsp. pallidum were investigated based on previous screening …

Current status of syphilis vaccine development: need, challenges, prospects

CE Cameron, SA Lukehart - Vaccine, 2014 - Elsevier
Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum
subsp. pallidum. Despite inexpensive and effective antibiotic therapy, syphilis remains a …