Prediction and pathogenesis in type 1 diabetes
AG Ziegler, GT Nepom - Immunity, 2010 - cell.com
A combination of genetic and immunological features is useful for prediction of autoimmune
diabetes. Patterns of immune response correspond to the progression from a preclinical …
diabetes. Patterns of immune response correspond to the progression from a preclinical …
T cells and their products in diabetic kidney disease
Y Liu, Y Lv, T Zhang, T Huang, Y Lang… - Frontiers in …, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and
has gradually become a public health problem worldwide. DKD is increasingly recognized …
has gradually become a public health problem worldwide. DKD is increasingly recognized …
Increased blood levels of growth factors, proinflammatory cytokines, and Th17 cytokines in patients with newly diagnosed type 1 diabetes
K Alnek, K Kisand, K Heilman, A Peet, K Varik, R Uibo - PloS one, 2015 - journals.plos.org
The production of several cytokines could be dysregulated in type 1 diabetes (T1D). In
particular, the activation of T helper (Th) type 1 (Th1) cells has been proposed to underlie …
particular, the activation of T helper (Th) type 1 (Th1) cells has been proposed to underlie …
Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)
K Waugh, J Snell-Bergeon, A Michels, F Dong… - PloS one, 2017 - journals.plos.org
Background Type 1 diabetes (TID) is characterized by a loss of pancreatic islet beta cell
function resulting in loss of insulin production. Genetic and environmental factors may trigger …
function resulting in loss of insulin production. Genetic and environmental factors may trigger …
Interleukin-7 expression in tears and orbital tissues of patients with Graves' ophthalmopathy
KB Cai, RL Wei - Endocrine, 2013 - Springer
The aim of this study was to explore whether IL-7 participates in the pathogenesis of Graves'
ophthalmopathy (GO). This was a prospective study. 20 GO patients (40 eyes) and 20 …
ophthalmopathy (GO). This was a prospective study. 20 GO patients (40 eyes) and 20 …
Serum titres of anti-glutamic acid decarboxylase-65 and anti-IA-2 autoantibodies are associated with different immunoregulatory milieu in newly diagnosed type 1 …
M Andrade Lima Gabbay, MN Sato… - Clinical & …, 2012 - academic.oup.com
Several studies correlated genetic background and pancreatic islet-cell autoantibody status
(type and number) in type 1A diabetes mellitus (T1AD), but there are no data evaluating the …
(type and number) in type 1A diabetes mellitus (T1AD), but there are no data evaluating the …
Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1-polarized CD4+ T cells from autoimmune-prone mice
SR Choudhury, SD Byrum, SJ Blossom - Toxicological Sciences, 2024 - academic.oup.com
Trichloroethylene (TCE) is an industrial solvent and widespread environmental contaminant
associated with CD4+ T-cell activation and autoimmune disease. Prior studies showed that …
associated with CD4+ T-cell activation and autoimmune disease. Prior studies showed that …
Developmental trichloroethylene exposure enhances predictive markers of autoimmunity in a sex-specific manner in disease-resistant female mice
SJ Blossom, CV Cabanlong, KK Vyas - Toxicology and applied …, 2022 - Elsevier
Trichloroethylene (TCE) is a widely used industrial chemical and common environmental
pollutant. Exposure to TCE promotes CD4+ T cell-driven autoimmunity including …
pollutant. Exposure to TCE promotes CD4+ T cell-driven autoimmunity including …
Immune profiling by multiple gene expression analysis in patients at-risk and with type 1 diabetes
D Han, CA Leyva, D Matheson, D Mineo… - Clinical …, 2011 - Elsevier
There is a need for biomarkers to monitor the development and progression of type 1 DM.
We analyzed mRNA expression levels for granzyme B, perforin, fas ligand, TNF-α, IFN-γ …
We analyzed mRNA expression levels for granzyme B, perforin, fas ligand, TNF-α, IFN-γ …
Healthy first‐degree relatives of patients with type 1 diabetes exhibit significant differences in basal gene expression pattern of immunocompetent cells compared to …
K Stechova, M Kolar, R Blatny… - Scandinavian …, 2012 - Wiley Online Library
Expression features of genetic landscape which predispose an individual to the type 1
diabetes are poorly understood. We addressed this question by comparing gene expression …
diabetes are poorly understood. We addressed this question by comparing gene expression …