Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Otoliths are bioinorganic minerals within the inner ear of all bony fishes. They grow
incrementally, laying down alternating protein-rich and mineral-rich bands daily …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully
restoring its size, shape and tissue patterning. Studies over the past decades have identified …

Reactive glia, including astroglia and oligodendrocyte progenitors (OPCs) are at the core of
the reaction to injury in the mammalian brain with initially beneficial and later partially …

Background The correct evaluation of mineralization is fundamental for the study of skeletal
development, maintenance, and regeneration. Current methods to visualize mineralized …

Osteoporosis is the second most common disease only secondary to cardiovascular
disease, with the risk of fracture increasing with age. Osteoporosis is caused by an …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …