In vivo cellular microenvironments are not well-mimicked in present in vitro cell culture
systems. Microtechnology, and microfluidics in particular, provides the tools to create in vivo …

The clinical and experimental literature has unequivocally established that mechanical
ventilation with large tidal volumes is injurious to the lung. However, uncertainty about the …

During angiogenesis, endothelial cells (ECs) from intact blood vessels quickly infiltrate
avascular regions via vascular sprouting. This process is fundamental to many normal and …

abstract Epithelial cells experience constant mechanical forces, including fluid shear stress
(FSS) on their apical surface. These forces alter both structure and function. While precise …

A numerical method for computing Stokes flows in the presence of immersed boundaries
and obstacles is presented. The method is based on the smoothing of the forces, leading to …

Biofilms are communities of sessile microbes that are phenotypically distinct from their
genetically identical, free-swimming counterparts. Biofilms initiate when bacteria attach to a …

We describe the design, construction, and characterization of microfluidic devices for
studying cell adhesion and cell mechanics. The method offers multiple advantages over …

Airway collapse and reopening due to mechanical ventilation exerts mechanical stress on
airway walls and injures surfactant-compromised lungs. The reopening of a collapsed …

Background The ability to properly model intravascular steps in metastasis is essential in
identifying key physical, cellular, and molecular determinants that can be targeted …

The last two decades have brought new insights into mechanisms of lung injury. These
insights have profoundly altered the ventilator management of patients with adult respiratory …