Despite tremendous investments in understanding the complex molecular mechanisms
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Microglia are immune system cells associated with Alzheimer's disease plaques containing
β-amyloid (Aβ). Murine microglia internalize microaggregates of fluorescently labeled or …

It has been demonstrated recently that β-amyloid protein (βAP), generally associated with
the plaques of Alzheimer's disease, can also be found in the brains of survivors of head …

Synaptic failure is an immediate cause of cognitive decline and memory dysfunction in
Alzheimer's disease. Dendritic spines are specialized structures on neuronal processes, on …

The aetiology and pathogenesis of Alzheimer's disease are currently poorly understood, but
symptomatic disease is associated with amyloid plaques, neurofibrillary tangles, neuronal …

Microglia are a key component of the inflammatory response in the brain and are associated
with senile plaques in Alzheimer's disease (AD). Although there is evidence that microglial …

To date, there is no reasonable explanation as to why plaques and tangles simultaneously
accumulate in Alzheimer's disease (AD). We demonstrate here by Western blotting and …

Amyloid-β precursor protein (APP) forms a transcriptionally active complex with the adaptor
protein Fe65 and the histone acetyltransferase Tip60, but the mechanism of transcriptional …

Background β-Amyloid precursor protein (APP) has been reported to play a role in the
outgrowth of neurites from cultured neurons. Both cell-surface APP and its soluble …