The present paper aims to establish different treatments for neglected tropical disease by a
survey on drug conjugations and possible fixed-dose combinations (FDC) used to obtain …

Schistosomiasis is a parasitic disease that endangers human health and social
development. The granulomatous reaction of Schistosoma eggs in the liver is the main …

Background The control of schistosomiasis has been centered to date on a single drug,
praziquantel, with shortcomings including treatment failure, reinfection, and emergence of …

Artemisone is an innovative artemisinin derivative with applications in the treatment of
malaria, schistosomiasis and other diseases. However, its low aqueous solubility and …

In this work, two synthetic aurones revealed moderate schistosomicidal potential in in vitro
and in vivo assays. Aurones (1) and (2) promoted changes in tegument integrity and motor …

Schistosomiasis is a neglected tropical disease associated with considerable morbidity.
Praziquantel (PZQ) is effective against adult schistosomes, yet, it has little effect on juvenile …

Schistosomiasis is one of the most prevalent parasitic diseases, accounting for heavy
socioeconomical and health burden in endemic countries. The control of this neglected …

Abstract Treatment of schistosomiasis is heavily reliant on the single antischistosomal drug
praziquantel (PZQ). The use of synergistic drug-drug interactions is one possible solution …

Background Schistosomiasis is a debilitating and neglected tropical disease for which
praziquantel (PZQ) remains the first-choice drug for treatment and control of the disease. In …

Chronic hepatic schistosomiasis causes portal hypertension, fibrosis and lethal
hepatosplenic complications. Previous studies focused mainly on schistosomicidal drugs …