Management of treatment-resistant depression: challenges and strategies
D Voineskos, ZJ Daskalakis… - … disease and treatment, 2020 - Taylor & Francis
Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …
which does not respond to traditional and first-line therapeutic options. There are several …
[HTML][HTML] A brain-centric model of suicidal behavior
The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …
Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant …
P Kopschina Feltes, J Doorduin… - Journal of …, 2017 - journals.sagepub.com
Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …
Kynurenine pathway in depression: A systematic review and meta-analysis
Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of
depression. However, the relationships between depression and each metabolite of the …
depression. However, the relationships between depression and each metabolite of the …
Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
Treatment for comorbid depressive disorder or subthreshold depression in diabetes mellitus: Systematic review and meta‐analysis
Objective To provide an estimate of the effect of interventions on comorbid depressive
disorder (MDD) or subthreshold depression in type 1 and type 2 diabetes. Methods …
disorder (MDD) or subthreshold depression in type 1 and type 2 diabetes. Methods …
Role of inflammation in suicide: from mechanisms to treatment
L Brundin, EY Bryleva… - …, 2017 - nature.com
Suicidal behavior is complex and manifests because of a confluence of diverse factors. One
such factor involves dysregulation of the immune system, which has been linked to the …
such factor involves dysregulation of the immune system, which has been linked to the …
Curcumin in depression: potential mechanisms of action and current evidence—a narrative review
T Ramaholimihaso, F Bouazzaoui… - Frontiers in psychiatry, 2020 - frontiersin.org
Major depressive disorder (MDD) is one of the most prevalent and debilitating disorders.
Current available treatments are somehow limited, so alternative therapeutic approaches …
Current available treatments are somehow limited, so alternative therapeutic approaches …
Minocycline as an adjunct for treatment-resistant depressive symptoms: a pilot randomised placebo-controlled trial
Background: Evidence suggests that anti-inflammatory medication may be effective in the
treatment of depressive symptoms. In this study, we aimed to investigate whether …
treatment of depressive symptoms. In this study, we aimed to investigate whether …
Guidelines for the recognition and management of mixed depression
A significant minority of people presenting with a major depressive episode (MDE)
experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may …
experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may …