Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Polyheterocycles are one of the most desired synthetic targets due to their numerous and
valuable applications in various fields. Multicomponent reactions (MCRs) are highly …

More than 60 years have passed since I. Ugi synthesized the first α-amidoamides in one
experimental step involving a combination of aldehydes, amines, carboxylic acids and …

An Ugi–Zhu three-component reaction (UZ-3CR) coupled in one pot manner to a cascade
process (N-acylation/aza Diels–Alder cycloaddition/decarboxylation/dehydration) was …

Abstract Ever since Amé Pictet and Theodor Spengler discovered their way to synthesize
tetrahydroisoquinolines and β-carbolines, their method became a powerful methodology for …

6-Triazolylmethyl-pyrrolo [3, 4-b] pyridin-5-one tris-heterocycles were synthesized in 43–
57% overall yields. The two-stage synthesis involved a cascade process (Ugi-3CR/aza Diels …

Propargylation of Ugi adducts under the addition of excess sodium hydride in DMSO leads
to direct formation of pyrrolidinone enamides, which are useful precursors of iminium …

A series of fifteen 2-tetrazolylmethyl-isoindolin-1-one linked-type bis-heterocycles were
synthesized in 10–76% yields under mild conditions via a one-pot Ugi-azide/(N …

A series of linked-type 1, 5-disubstituted tetrazoles (1, 5-DS-Ts) were synthesised via an
isocyanide-based multicomponent reaction (IMCR) and used as synthetic platforms to …

A series of 12 polysubstituted pyrrolo [3, 4-b] pyridin-5-ones were synthesized via a one-pot
cascade process (Ugi–3CR/aza Diels-Alder/N-acylation/decarboxylation/dehydration) and …