Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
Recent advances on quinazoline derivatives: A potential bioactive scaffold in medicinal chemistry
This paper intended to explore and discover recent therapeutic agents in the area of
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …
An overview of quinazolines: Pharmacological significance and recent developments
V Alagarsamy, K Chitra, G Saravanan… - European journal of …, 2018 - Elsevier
Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …
structures and presence of hetero atoms or groupings divulges privileged specificities in …
Pyrimidine: a review on anticancer activity with key emphasis on SAR
A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …
treatment is associated with several side effects. Resistance of the cancer cells to the …
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review
Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …
incidences are reported annually. Heterocyclic compounds have been proved to be very …
Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents
The present article describes the design, synthesis, in vitro urease inhibition, and in silico
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
In-silico activity prediction, structure-based drug design, molecular docking and pharmacokinetic studies of selected quinazoline derivatives for their antiproliferative …
Background Cancer is a major health threat especially in unindustrialized nations. It
surpasses coronary diseases and takes the number one killer position as a result of different …
surpasses coronary diseases and takes the number one killer position as a result of different …
Cell cycle arrest and apoptosis-inducing ability of benzimidazole derivatives: design, synthesis, docking, and biological evaluation
S Nazreen, ASA Almalki, SEI Elbehairi, AA Shati… - Molecules, 2022 - mdpi.com
In the current study, new benzimidazole-based 1, 3, 4-oxadiazole derivatives have been
synthesized and characterized by NMR, IR, MS, and elemental analysis. The final …
synthesized and characterized by NMR, IR, MS, and elemental analysis. The final …
Molecular docking and anticonvulsant activity of newly synthesized quinazoline derivatives
HA Abuelizz, R El Dib, M Marzouk, EH Anouar… - Molecules, 2017 - mdpi.com
A new series of quinazoline-4 (3 H)-ones are evaluated for anticonvulsant activity. After
intraperitoneal (ip) injection to albino mice at a dose of 100 mg/kg body weight, synthesized …
intraperitoneal (ip) injection to albino mice at a dose of 100 mg/kg body weight, synthesized …
Isolation of plant-derived exosome-like nanoparticles (PDENs) from Solanum nigrum L. berries and Their Effect on interleukin-6 expression as a potential anti …
Inflammation is a temporary response of the immune system that can be treated using
common anti-inflammatory drugs. However, prolonged use of these drugs increases the risk …
common anti-inflammatory drugs. However, prolonged use of these drugs increases the risk …