This article reviews the role of norepinephrine (NE) and serotonin (5-HT) in depression and
the therapeutic effects of antidepressant drugs from the perspective of human …

Depression is a common disorder that impacts on all aspects of a person's life. For the past
10 years, clinicians have focused on serotonin in their treatment of depression. This is …

Background: We wished to examine the integrity of the noradrenergic system in patients with
Alzheimer's disease, mixed/other dementias and controls, and possible relationships …

In this review, we examine the history of the neurobiology of suicide, as well as the genetics,
molecular and neurochemical findings in suicide research. Our analysis begins with a …

Noradrenergic and/or serotonergic deficits, as well as other abnormalities, may contribute to
predisposition to some epilepsies and depressions. Evidence for this hypothesis stems from …

This chapter reviews the current status of genetic, brain imaging, postmortem, and animal
model research relevant to elucidating the pathophysiology of mental disorders. This is …

Brain-derived neurotrophic factor (BDNF) is a member of the structurally and functionally
homologous neurotrophin family. It is the most widely distributed trophic factor in the brain …

A model for the pathophysiology of depression is discussed in the context of other existing
theories. The classic monoamine theory of depression suggests that a deficit in monoamine …

With recent studies using genetic, epigenetic, and other molecular and neurochemical
approaches, a new era has begun in understanding pathophysiology of suicide. Emerging …

The medial prefrontal cortex (mPFC) has been proposed to play a role in the inhibition of
hypothalamo-pituitary-adrenal (HPA) responses to emotional stress via influences on …