Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …

The gut microbiome is increasingly recognized to play an important role in shaping the
health and fitness of animals, including humans. Drosophila is emerging as a valuable …

Pangenome references address biases of reference genomes by storing a representative
set of diverse haplotypes and their alignment, usually as a graph. Alternate alleles …

FlyBase (flybase. org) is an essential online database for researchers using Drosophila
melanogaster as a model organism, facilitating access to a diverse array of information that …

Chromatin topology is intricately linked to gene expression, yet its functional requirement
remains unclear. Here, we comprehensively assessed the interplay between genome …

Precise patterns of synaptic connections between neurons are encoded in their genetic
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …

Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Studies in model organisms have yielded considerable insights into the etiology of disease
and our understanding of evolutionary processes. Caenorhabditis elegans is among the …

High quality reference genomes are crucial to understanding genome function, structure and
evolution. The availability of reference genomes has allowed us to start inferring the role of …

Embryogenesis is remarkably robust to segregating mutations and environmental variation;
under a range of conditions, embryos of a given species develop into stereotypically …