The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two
hormones, FGF23 and osteocalcin, which regulate kidney function and glucose …

The capacity to adjust food intake in response to changing energy requirements is essential
for survival. Recent progress has provided an insight into the molecular, cellular and …

Excess weight gain contributes to increased blood pressure in most patients with essential
hypertension. Although the mechanisms of obesity hypertension are not fully understood …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

Insulin action in the central nervous system regulates energy homeostasis and glucose
metabolism. To define the insulin-responsive neurons that mediate these effects, we …