The extracellular matrix (ECM) is a complex assembly of proteins that constitutes the scaffold
organizing cells, tissues, and organs. Over the past decade, mass-spectrometry-based …

Electron cryo-tomography using the scanning transmission modality (STEM) enables 3D
reconstruction of unstained, vitrified specimens as thick as 1 μm or more. Contrast is related …

Advanced therapies in medicine use stem cells, gene editing, and tissues to treat a wide
range of conditions. One of their goals is to stimulate endogenous repair of tissues and …

The extracellular matrix (ECM) serves as a scaffold for cells and plays an essential role in
regulating numerous cellular processes, including cell migration and proliferation. Due to …

Biosensors are aimed at detecting tiny physical and chemical stimuli in biological systems.
Physical forces are ubiquitous, being implied in all cellular processes, including cell …

Atomic Force Microscopy (AFM) is successfully used for the quantitative investigation of the
cellular mechanosensing of the microenvironment. To this purpose, several force …

Visualization of organelles and their interactions with other features in the native cell
remains a challenge in modern biology. We have introduced cryo-scanning transmission …

Cell migration plays an important role in physiological and pathological processes where
the fibrillar morphology of extracellular matrices (ECM) could regulate the migration …

Mechanosensing, the ability of cells to perceive and interpret the microenvironmental
biophysical cues (such as the nanotopography), impacts strongly cellular behaviour through …

The extracellular matrix (ECM) is a complex assembly of proteins that provide interstitial
scaffolding and elastic recoil for human lungs. The pulmonary extracellular matrix is …