Astrocytes are the most numerous type of neuroglia in the brain and have a predominant
influence on the cerebrovascular system; they control perivascular homeostasis, the integrity …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

The glymphatic system is a recently defined brain‐wide network of perivascular spaces
along which cerebrospinal fluid (CSF) and interstitial solutes exchange. Astrocyte endfeet …

Simple Summary Intracerebral hemorrhage (ICH) is a leading medical problem without
effective treatment options. The poor prognosis is attributed to the primary brain injury of the …

In the mammalian brain, perivascular astrocytes (PAs) closely juxtapose blood vessels and
are postulated to have important roles in the control of vascular physiology, including …

Major depressive disorder (MDD) is a leading chronic mental illness worldwide,
characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43) …

Astrocytes are a population of central nervous system (CNS) cells with distinctive
morphological and functional characteristics that differ within specific areas of the brain and …

Astrocytes, the main glial cells of the central nervous system, play a key role in brain volume
control due to their intimate contacts with cerebral blood vessels and the expression of a …

Background MLC1 is a membrane protein highly expressed in brain perivascular astrocytes
and whose mutations account for the rare leukodystrophy (LD) megalencephalic …

Abstract Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a type of
vacuolating leukodystrophy, which is mainly caused by mutations in MLC1 or GLIALCAM …