Protein coding mutations in leucine‐rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD), and noncoding variations around the gene increase the risk of developing …

Although the role of gut microbiota (GMB)-derived metabolites in mitochondrial and
endolysosomal dysfunction in Alzheimer's disease (AD) under metabolic syndrome remains …

ABSTRACT A growing number of studies have shown that melatonin is a potent agonist of
SIRT3 (sirtuin 3) and effectively protects mitochondria, suggesting melatonin as a promising …

Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal
circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial …

The ability to adapt to environmental stress, including therapeutic insult, contributes to tumor
evolution and drug resistance. In suboptimal conditions, the integrated stress response (ISR) …

Background Sepsis-caused multi-organ failure remains the major cause of morbidity and
mortality in intensive care units with limited therapeutics. Nicotinamide mononucleotide …

Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial
disorders are associated with various cardiac diseases. We previously showed that mice …

BACKGROUND: Chronic overconsumption of lipids followed by their excessive
accumulation in the heart leads to cardiomyopathy. The cause of lipid-induced …

Abstract The 3243A> G in mtDNA is a representative mutation in mitochondrial diseases.
Mitochondrial protein synthesis is impaired due to decoding disorder caused by severe …

Mesenchymal stem cell (MSC) transplantation has been widely used as a potential
treatment for a variety of diseases. However, the contradiction between the low survival rate …