Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …

The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …

Clonal evolution represents the natural process through which cancer cells continuously
search for phenotypic advantages that enable them to develop and expand within …

Intraclonal diversification (ID) within the immunoglobulin (IG) genes expressed by B cell
clones arises due to ongoing somatic hypermutation (SHM) in a context of continuous …

High throughput sequencing of adaptive immune receptor repertoire (AIRR-seq) has
provided numerous human immunoglobulin (IG) sequences allowing specific B cell receptor …

Comprehensive study of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements
has proven instrumental for understanding immune responses in health and disease, while …

Although monoclonal antibodies to the severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) are known, B‐cell receptor repertoire and its change in patients during …

Classification of patients with chronic lymphocytic leukemia (CLL) based on the somatic
hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene …

Background Previous investigations pointed out a role for antigen stimulation in Sezary
syndrome (SS). High‐throughput sequencing of the T cell receptor (TR) offers several …

Activation-induced cytidine deaminase (AID) has been implicated as both a positive and a
negative factor in the progression of B cell chronic lymphocytic leukemia (CLL), but the role …