Executioner caspases, when activated, cleave hundreds or thousands of substrates in the
cell to orchestrate apoptosis. In most animals, the executioner caspases have short …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Inhibitors of programmed cell death (apoptosis) aberrantly prolonging cell viability may
contribute to cancer1 by facilitating the insurgence of mutations and by promoting resistance …

Coordination between cell proliferation and cell death is essential to maintain homeostasis
in multicellular organisms. In Drosophila, these two processes are regulated by a pathway …

Apoptosis is a physiological cell suicide program that is critical for the development and
maintenance of healthy tissues. Dysregulation of cell death pathways occur in cancer …

To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we
used coimmunoprecipitation and 2D immobilized pH gradient/SDS PAGE, followed by …

The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in
regulating programmed cell death in animals ranging from insects to humans,,,,,. Ectopic …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

The coordination between cell proliferation and cell death is essential to maintain
homeostasis within multicellular organisms. The mechanisms underlying this regulation are …

Physiological mechanisms of cell death are used by multicellular organisms for
development and morphogenesis, to control cell number, and as a defensive strategy to …