CD44: the hyaluronan receptor

C Underhill - Journal of cell science, 1992 - journals.biologists.com
Over the past decade, the International Workshop on Human Leucocyte Differentiation
Antigens has set about organizing the myriad of proteins found on the surfaces of white …

Hyaluronic acid and hyaluronic acid-binding proteins in brain extracellular matrix

A Bignami, M Hosley, D Dahl - Anatomy and embryology, 1993 - Springer
Hyaluronic acid (HA) plays the main structural role in the formation of brain extracellular
matrix (ECM). The extracellular space appears empty by electron microscopy because HA is …

CD44 is the principal cell surface receptor for hyaluronate

A Aruffo, I Stamenkovic, M Melnick, CB Underhill… - Cell, 1990 - cell.com
CD44 is a broadly distributed cell surface protein thought to mediate cell attachment to
extracellular matrix components or specific cell surface ligands. We have created soluble …

The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan.

M Culty, HA Nguyen, CB Underhill - The Journal of cell biology, 1992 - ncbi.nlm.nih.gov
The hyaluronan receptor belongs to the polymorphic family of CD44 glycoproteins, which
have been implicated in a variety of cellular functions including adhesion to hyaluronan and …

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

HC DeGrendele, P Estess, LJ Picker… - The Journal of …, 1996 - ncbi.nlm.nih.gov
The extravasation of leukocytes from the blood into tissues occurs as a multistep process: an
initial transient interaction (" rolling"), generally thought to be mediated by the selectin family …

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

PD Gottlieb, SA Pierce, RJ Sims, H Yamagishi… - Nature …, 2002 - nature.com
Many transcription factors regulate specific temporal-spatial events during cardiac
differentiation; however, the mechanisms that regulate such events are largely unknown …

Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition.

K Miyake, CB Underhill, J Lesley… - The Journal of …, 1990 - europepmc.org
A cell adhesion model was previously used to select a series of monoclonal antibodies
(mAbs), which were subsequently found to recognize CD44/Pgp-1. Interest in these …

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

PW Noble, FR Lake, PM Henson… - The Journal of clinical …, 1993 - Am Soc Clin Investig
Macrophages participate in inflammatory and repair processes in part through the selective
release of cytokines that contribute to tissue remodeling. Extracellular matrix components …

Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion.

M Mohamadzadeh, H DeGrendele… - The Journal of …, 1998 - Am Soc Clin Investig
The localization of circulating leukocytes within inflamed tissues occurs as the result of
interactions with and migration across vascular endothelium, and is governed, in part, by the …

The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins.

M Culty, K Miyake, PW Kincade, E Sikorski… - The Journal of cell …, 1990 - rupress.org
The present study was undertaken to determine the relationship between the hyaluronate
receptor and CD44 (H-CAM), cell-surface glycoproteins of similar molecular weights that …