Models and mechanisms of vascular dementia

P Venkat, M Chopp, J Chen - Experimental neurology, 2015 - Elsevier
Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease
(AD) plaguing the elderly population. VaD is a progressive disease caused by reduced …

[HTML][HTML] The blood brain barrier in cerebral ischemic injury–Disruption and repair

W Zhang, L Zhu, C An, R Wang, L Yang, W Yu, P Li… - Brain …, 2020 - Elsevier
With the emergence of novel technologies and ground breaking concepts in BBB basic
research in the past decades, the researchers' attention on the critical role of blood brain …

Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy

CM Cotten, AP Murtha, RN Goldberg, CA Grotegut… - The Journal of …, 2014 - Elsevier
Objective To assess feasibility and safety of providing autologous umbilical cord blood
(UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE). Study design We …

Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety

M Tsuji, M Sawada, S Watabe, H Sano, M Kanai… - Scientific Reports, 2020 - nature.com
Neonatal hypoxic-ischaemic encephalopathy (HIE) is a serious condition; many survivors
develop neurological impairments, including cerebral palsy and intellectual disability …

Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies

I Serrenho, M Rosado, A Dinis, C M. Cardoso… - International Journal of …, 2021 - mdpi.com
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and
morbidity in the perinatal period. This condition results from a period of ischemia and …

Therapies for neonatal encephalopathy: Targeting the latent, secondary and tertiary phases of evolving brain injury

AA Chakkarapani, H Aly, M Benders, CM Cotten… - Seminars in Fetal and …, 2021 - Elsevier
In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

Stem cell therapy to protect and repair the developing brain: a review of mechanisms of action of cord blood and amnion epithelial derived cells

M Castillo-Melendez, T Yawno, G Jenkin… - Frontiers in …, 2013 - frontiersin.org
In the research, clinical, and wider community there is great interest in the use of stem cells
to reduce the progression, or indeed repair brain injury. Perinatal brain injury may result …

Neuroprotection of stem cells against ischemic brain injury: from bench to clinic

X Liu, X Jia - Translational Stroke Research, 2023 - Springer
Neurological injuries can have numerous debilitating effects on functional status including
sensorimotor deficits, cognitive impairment, and behavioral symptoms. Despite the disease …

Neonatal hypoxic–ischemic encephalopathy: Emerging therapeutic strategies based on pathophysiologic phases of the injury

Q Wang, H Lv, L Lu, P Ren, L Li - The Journal of Maternal-Fetal & …, 2019 - Taylor & Francis
Neonatal hypoxic ischemic encephalopathy (HIE) is an important cause of neonatal death
and disability. At present, there is no unified standard and specialized treatment method for …

Dose-dependent effect of intravenous administration of human umbilical cord-derived mesenchymal stem cells in neonatal stroke mice

E Tanaka, Y Ogawa, T Mukai, Y Sato… - Frontiers in …, 2018 - frontiersin.org
Neonatal brain injury induced by stroke causes significant disability, including cerebral
palsy, and there is no effective therapy for stroke. Recently, mesenchymal stem cells (MSCs) …