Mechanism of action of ribosomally synthesized and post-translationally modified peptides
C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …
product class that has undergone significant expansion due to the rapid growth in genome …
Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
Background Reducing the burden of death due to infection is an urgent global public health
priority. Previous studies have estimated the number of deaths associated with drug …
priority. Previous studies have estimated the number of deaths associated with drug …
The IUPHAR/BPS guide to PHARMACOLOGY in 2024
SD Harding, JF Armstrong, E Faccenda… - Nucleic acids …, 2024 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.
guidetopharmacology. org) is an open-access, expert-curated, online database that …
guidetopharmacology. org) is an open-access, expert-curated, online database that …
Antibiotic discovery and resistance: the chase and the race
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …
Adding flying wings: butterfly-shaped NIR-II AIEgens with multiple molecular rotors for photothermal combating of bacterial biofilms
The ever-increasing threats of multidrug-resistant bacteria and their biofilm-associated
infections have bred a desperate demand for alternative remedies to combat them. Near …
infections have bred a desperate demand for alternative remedies to combat them. Near …
PLSDB: advancing a comprehensive database of bacterial plasmids
Plasmids are known to contain genes encoding for virulence factors and antibiotic
resistance mechanisms. Their relevance in metagenomic data processing is steadily …
resistance mechanisms. Their relevance in metagenomic data processing is steadily …
Potent antibiotic design via guided search from antibacterial activity evaluations
L Chen, L Yu, L Gao - Bioinformatics, 2023 - academic.oup.com
Motivation The emergence of drug-resistant bacteria makes the discovery of new antibiotics
an urgent issue, but finding new molecules with the desired antibacterial activity is an …
an urgent issue, but finding new molecules with the desired antibacterial activity is an …
Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
[HTML][HTML] An antibiotic from an uncultured bacterium binds to an immutable target
Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …