Biophysical Modeling of Synaptic Plasticity

CT Lee, M Bell, M Bonilla-Quintana… - Annual Review of …, 2024 - annualreviews.org
Dendritic spines are small, bulbous compartments that function as postsynaptic sites and
undergo intense biochemical and biophysical activity. The role of the myriad signaling …

Linking spontaneous and stimulated spine dynamics

MF Eggl, TE Chater, J Petkovic, Y Goda… - Communications …, 2023 - nature.com
Our brains continuously acquire and store memories through synaptic plasticity. However,
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …

Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling

A Leung, P Rangamani - npj Systems Biology and Applications, 2023 - nature.com
Neuronal energy consumption is vital for information processing and memory formation in
synapses. The brain consists of just 2% of the human body's mass, but consumes almost …

Spatial modeling algorithms for reactions and transport in biological cells

EA Francis, JG Laughlin, JS Dokken… - Nature Computational …, 2024 - nature.com
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to
control their functions. Such cell signaling networks have been a common focus for …

Spatiotemporal modelling reveals geometric dependence of AMPAR dynamics on dendritic spine morphology

MK Bell, CT Lee, P Rangamani - The Journal of Physiology, 2023 - Wiley Online Library
The modification of neural circuits depends on the strengthening and weakening of synaptic
connections. Synaptic strength is often correlated to the density of the ionotropic …

[HTML][HTML] Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome

K Venkatraman, CT Lee, GC Garcia, A Mahapatra… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cristae are high curvature structures in the inner mitochondrial membrane (IMM) that are
crucial for ATP production. While cristae-shaping proteins have been defined, analogous …

Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity

MK Bell, P Rangamani - The Journal of Physiology, 2023 - Wiley Online Library
Synaptic plasticity involves modification of both biochemical and structural components of
neurons. Many studies have revealed that the change in the number density of the …

Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop

L Qiao, M Getz, B Gross, B Tenner… - PLOS Computational …, 2024 - journals.plos.org
The nanoscale organization of enzymes associated with the dynamics of second
messengers is critical for ensuring compartmentation and localization of signaling molecules …

Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks

MH Mesa, G Garcia, F Hoerndli, KJ McCabe… - Biophysical …, 2024 - cell.com
Dendritic spines are small protrusions on dendrites in neurons and serve as sites of
postsynaptic activity. Some of these spines contain smooth endoplasmic reticulum (SER) …

A FAIR, open-source virtual reality platform for dendritic spine analysis

ML Reimer, SD Kauer, CA Benson, JF King, S Patwa… - Patterns, 2024 - cell.com
Neuroanatomy is fundamental to understanding the nervous system, particularly dendritic
spines, which are vital for synaptic transmission and change in response to injury or …