Biophysical Modeling of Synaptic Plasticity
CT Lee, M Bell, M Bonilla-Quintana… - Annual Review of …, 2024 - annualreviews.org
Dendritic spines are small, bulbous compartments that function as postsynaptic sites and
undergo intense biochemical and biophysical activity. The role of the myriad signaling …
undergo intense biochemical and biophysical activity. The role of the myriad signaling …
Linking spontaneous and stimulated spine dynamics
MF Eggl, TE Chater, J Petkovic, Y Goda… - Communications …, 2023 - nature.com
Our brains continuously acquire and store memories through synaptic plasticity. However,
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …
Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling
A Leung, P Rangamani - npj Systems Biology and Applications, 2023 - nature.com
Neuronal energy consumption is vital for information processing and memory formation in
synapses. The brain consists of just 2% of the human body's mass, but consumes almost …
synapses. The brain consists of just 2% of the human body's mass, but consumes almost …
Spatial modeling algorithms for reactions and transport in biological cells
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to
control their functions. Such cell signaling networks have been a common focus for …
control their functions. Such cell signaling networks have been a common focus for …
Spatiotemporal modelling reveals geometric dependence of AMPAR dynamics on dendritic spine morphology
MK Bell, CT Lee, P Rangamani - The Journal of Physiology, 2023 - Wiley Online Library
The modification of neural circuits depends on the strengthening and weakening of synaptic
connections. Synaptic strength is often correlated to the density of the ionotropic …
connections. Synaptic strength is often correlated to the density of the ionotropic …
[HTML][HTML] Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome
Cristae are high curvature structures in the inner mitochondrial membrane (IMM) that are
crucial for ATP production. While cristae-shaping proteins have been defined, analogous …
crucial for ATP production. While cristae-shaping proteins have been defined, analogous …
Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity
MK Bell, P Rangamani - The Journal of Physiology, 2023 - Wiley Online Library
Synaptic plasticity involves modification of both biochemical and structural components of
neurons. Many studies have revealed that the change in the number density of the …
neurons. Many studies have revealed that the change in the number density of the …
Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop
The nanoscale organization of enzymes associated with the dynamics of second
messengers is critical for ensuring compartmentation and localization of signaling molecules …
messengers is critical for ensuring compartmentation and localization of signaling molecules …
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks
Dendritic spines are small protrusions on dendrites in neurons and serve as sites of
postsynaptic activity. Some of these spines contain smooth endoplasmic reticulum (SER) …
postsynaptic activity. Some of these spines contain smooth endoplasmic reticulum (SER) …
A FAIR, open-source virtual reality platform for dendritic spine analysis
ML Reimer, SD Kauer, CA Benson, JF King, S Patwa… - Patterns, 2024 - cell.com
Neuroanatomy is fundamental to understanding the nervous system, particularly dendritic
spines, which are vital for synaptic transmission and change in response to injury or …
spines, which are vital for synaptic transmission and change in response to injury or …