Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous
system, leading to neurodegeneration and manifesting as a variety of symptoms. These can …

Background: Multiple sclerosis (MS) is a multifocal inflammatory central nervous system
disorder. There are now many highly effective disease-modifying therapies (DMTs) available …

Objective This study was undertaken to investigate the gut microbiome in progressive
multiple sclerosis (MS) and how it relates to clinical disease. Methods We sequenced the …

Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …

Background: In the phase III ASCLEPIOS I and II trials, participants with relapsing multiple
sclerosis receiving ofatumumab had significantly better clinical and magnetic resonance …

Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial
demyelinating disease of the central nervous system. MS is characterized by a wide range of …

Multiple sclerosis (MS) is an autoimmune, chronic, progressive disease leading to a
combination of inflammation, demyelination, and neurodegeneration throughout the central …

Background and Objectives To investigate whether white matter lesion activity, acute axonal
damage, and axonal density in MS associate with CSF neurofilament light chain (NfL) levels …

Abstract Background and Purpose Multiple sclerosis (MS) is an unpredictable disease
characterised by a highly variable disease onset and clinical course. Three main clinical …

Despite the success of disease-modifying treatments in relapsing multiple sclerosis, for
many individuals living with multiple sclerosis, progressive disability continues to accrue …