BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …

Endometrial cancer is the most common gynaecological malignancy in Europe and North
America. Traditional classification of endometrial carcinoma is based either on clinical and …

Background Endometriosis, defined as the presence of ectopic endometrial stroma and
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic …

Recent advances in molecular studies, especially genome-wide analyses, have revealed
the landscape of genomic alterations present in endometrial carcinomas, and have provided …

ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of
cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of …

The AT-rich interacting domain‑containing protein 1A gene (ARID1A) encodes ARID1A, a
member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces …

Abstract ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms
originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in …

Recent studies have detailed the genomic landscape of primary endometrial cancers, but
the evolution of these cancers into metastases has not been characterized. We performed …

Endometriosis is a condition characterized by the presence of endometrial tissue outside the
uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread …

Endometriosis is a benign gynecologic condition affecting up to one woman out of ten of
reproductive age. It is defined by the presence of endometrial-like tissue in localizations …