Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …

The clinical and cytogenetic findings associated with mosaicism for trisomy 21/Down
syndrome are the focus of this review. The primary topics discussed in this overview of the …

Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes
or orthologs, provide insights into better understanding and treatment options. The only …

Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological
hallmarks of DS include atypical central nervous system development that manifests …

Purpose: Several studies have shown substantially longer survival among persons with
Down syndrome in recent decades. We examined survival patterns among Danish persons …

An organism or cell carrying a number of chromosomes that is not a multiple of the haploid
count is in a state of aneuploidy. This condition results in significant changes in the level of …

Background Much interest has not been placed on the role of chromosomal abnormalities in
the pathogenesis and rising prevalence of infertility in recent times. This review was …

Mouse models of Down syndrome (DS) have been invaluable tools for advancing
knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts …

Robertsonian translocations (ROBs) have an estimated incidence rate of 1/1000 births,
making this type of rearrangement the most common structural chromosomal abnormalities …